국가연구개발성과
논문 (학술지)
Soyasaponin Ab of germinated soygerm extract ameliorate obesity via inhibition of adipogenesis and beige/brown fat activation
| 등록번호 | - | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
비SCI |
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| 저자명 (주·공동저자) | 서우덕 ; 강현중; 이미자; 장기창; 김현영; 함현미; 이광식; 신혜림; 김신혜; 최식원 ※ 과제 참여정보와 일치하는 연구자 상세정보로 정확하지 않을 수 있습니다. 동일저자 논문보기 |
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| 논문구분 | 국외기타논문집 | 학술지명 | - |
| ISSN | 0000-0000 | 학술지 출판일자 | - |
| 학술지 볼륨번호 | 0(0) | 논문페이지 | 1 ~ 10 |
| 학술지 임팩트팩터 | 0.0 | 기여율 | 100 % |
| 초록 | Obesity is a worldwide public health concern asking for safe dietary strategies. Recent studies suggest that bioactive compounds from soy or soybeans have beneficial effects on weight loss and reducing fat accumulation. However, despite the biochemical and nutritional changes during germination, the effects of germinated soy germ were not fully investigated. In this study, we investigated the effects of germinated soy germ extracts (GSGE) on 3T3-L1 pre-adipocytes and high-fat diet induced obese animal models. GSGE treatment suppressed 3T3-L1 cells to differentiate into mature adipocytes, along with the reduced lipid accumulation and lipid droplet formation. In vivo studies also showed that GSGE treatment reduced weight gain, decreased adipocyte area, reduced serum level of triglyceride and LDL-cholesterol in HFD-fed mice. Gene expression analysis of adipogenic factor (C/EBP-, SREBP-1c) and lipogenic factors (FAS, SCD-1) were down-regulated in both in vitro and in vivo study. In addition, GSGE treatment increased the expression levels of beige fat activation (UCP1, CIDEA, CPT1, PPAR-α), beta oxidation (ACOX1) lipolysis (ATGL, HSL) in all concentration of GSGE. However, gene expression levels of lipid droplet and triglyceride synthesis-related genes (Plin1, Caveolin, CGI-58, ASCL1, 4) were down-regulated only in low concentrations of GSGE. The present study provides evidences that GSGE is effective in inhibiting adipo- and lipogenesis and accelerating energy consumption through activation of beige fat activation even under excessive caloric intake. These results demonstrate that GSGE can be a promising dietary strategy for the prevention of obesity by promoting weight loss, reducing fat accumulation, and improving obesity-related glucose tolerance and insulin resistance | ||
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