논문 (학술지)
유치치수유래 줄기세포치료제의 조직재생 임상적용 위한 가능성 고찰
등록번호 | - | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
비SCI |
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저자명 (주·공동저자) | 윤지영 ※ 과제 참여정보와 일치하는 연구자 상세정보로 정확하지 않을 수 있습니다. |
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논문구분 | 국외전문학술지 | 학술지명 | 대한치과의사협회지 (Journal of Korean Dental Association) |
ISSN | 0376-4672 | 학술지 출판일자 | 2024-01-31 |
학술지 볼륨번호 | 62(3) | 논문페이지 | 150 ~ 163 |
학술지 임팩트팩터 | 0.1 | 기여율 | 30 % |
DOI | https://doi.org/ | ||
초록 | Dental pulp stem cells (DPSC) are mesenchymal stem cells derived from the dental pulp tissue of permanent or deciduous teeth. Especially, stem cells from human exfoliated deciduous teeth (SHED) have an enhanced capacity than DPSCs for self-renewal (proliferation) and multilineage differentiation, being able to generate dentin/pulp-like complexes, neural cells, skin cells, chondrocytes and osteogenic cells, among others. Their accessibility from routine dental procedures and lack of ethical concerns make SHED an attractive stem cell source for regenerative therapy. This paper reviews current preclinical and clinical research on the tissue regenerative potential of SHED-based therapies. In preclinical animal models and clinical trials, SHED transplantation have shown promise for bone regeneration and repair, neural regeneration, myocardial infarction treatment, inflammatory bowel disease, renal injury, liver fibrosis, diabetes mellitus, erectile dysfunction, skin wounds, muscle injury, and other conditions. Early-phase human trials further indicate the feasibility, safety, and efficacy of using SHED for various disease introduced before. However, therapeutic effects from SHED injections vary greatly depending on cell source, delivery method, dose, and disease model or condition. Additional studies elucidating key therapeutic mechanisms of SHED and methodological advances in cell processing and delivery are needed to improve consistency. If the remaining challenges are addressed through rigorous research, SHED therapy may become a versatile clinical tool for tissue repair and regeneration across a wide range of organs and disease states. |
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