논문 (학술지)
Comparison between reflectance confocal microscopy and 2-photon microscopy in early detection of cutaneous radiation injury in a mouse model in vivo
등록번호 | RPMS-2019-0190759456 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
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저자명 (주·공동저자) | Jang Won Hyuk ※ 과제 참여정보와 일치하는 연구자 상세정보로 정확하지 않을 수 있습니다. |
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논문구분 | 국외전문학술지 | 학술지명 | JOURNAL OF BIOPHOTONICS |
ISSN | 1864-063X | 학술지 출판일자 | - |
학술지 볼륨번호 | 11 | 논문페이지 | 0 ~ - |
학술지 임팩트팩터 | 0.0 | 기여율 | 50 % |
DOI | 10.1002/jbio.201700337 | ||
초록 | Cutaneous radiation injury (CRI) is a skin injury caused by high‐dose exposure of ionizing radiation (IR). For proper treatment, early detection of CRI before clinical symptoms is important. Optical microscopic techniques such as reflectance confocal microscopy (RCM) and 2‐photon microscopy (TPM) have been tested as the early diagnosis method by detecting cellular changes. In this study, RCM and TPM were compared in the detection of cellular changes caused by CRI in an in vivo mouse model. CRI was induced on the mouse hindlimb skin with various IR doses and the injured skin regions were imaged longitudinally by both modalities until the onset of clinical symptoms. Both RCM and TPM detected the changes of epidermal cells and sebaceous glands before clinical symptoms in different optical contrasts. RCM detected changes of cell morphology and scattering property based on light reflection. TPM detected detail changes of cellular structures based on autofluorescence of cells. Since both RCM and TPM were sensitive to the early stage CRI by using different contrasts, the optimal method for clinical CRI diagnosis could be either individual methods or their combination. |
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