국가연구개발성과
논문 (학술지)
Enzyme-assisted extraction, chemical characteristics, and immunostimulatory activity of polysaccharides from Korean ginseng (Panax ginseng Meyer)
| 등록번호 | RPMS-2019-0190759198 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
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| 저자명 (주·공동저자) | Song Young-Ran ; Sung Su-Kyung; Jang Mi; Lim Tae-Gyu; Cho Chang-Won; Han Chun-Ji; Hong Hee-Do ※ 과제 참여정보와 일치하는 연구자 상세정보로 정확하지 않을 수 있습니다. 동일저자 논문보기 |
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| 논문구분 | 국외전문학술지 | 학술지명 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES |
| ISSN | 0141-8130 | 학술지 출판일자 | 2018-05-20 |
| 학술지 볼륨번호 | 116 | 논문페이지 | 1089 ~ 1097 |
| 학술지 임팩트팩터 | 3.909 | 기여율 | 100 % |
| DOI | 10.1016/j.ijbiomac.2018.05.132 | ||
| 초록 | In this study, enzyme-assisted extraction was used to isolate functional polysaccharides from Korean ginseng (Panax ginseng Meyer) and the physicochemical and biological properties of the extracted polysaccharides were investigated, comparing with those from traditional hot-water extraction (FGWP). In macrophages, their effects on cytokines production could be ordered as FGEP-CA ≥ FGEP-A N FGEP-C N FGWP, suggesting that FGEP-CA (combined cellulase- and α-amylase-extracted polysaccharide) is a potent immunostimulator. In addi�tion, enzymatic digestion led to differences in the monosaccharide profile of the extract. FGWP mainly consisted of rhamnose, arabinose, galactose, galacturonic acid, and glucose in molar percentages of 1.8:10.1:9.2:17.8:60.6, whereas FGEP-CA was 3.2:11.4:16.5:22.3:45.8, respectively, suggesting that enzyme-assisted extraction of gin�seng polysaccharides produces a higher proportion of pectin polysaccharides. The HPLC profile of FGEP-CA also showed lower and more heterogeneous molecular weights than FGWP did. In cyclophosphamide-induced im�munosuppressed mice, FGEP-CA administration ameliorated decreased spleen and thymus indices (200 mg/kg), lymphocyte proliferation, natural killer cell activity, leukocyte counts, and the serum cytokines, interleukin-2, interleukin-6, and interferon-γ (100 and 200 mg/kg). These results suggest that enzyme�assisted extraction using cellulase and α-amylase is an effective method for the preparation of functional polysac�charides from fresh Korean ginseng, and FGEP-CA could be utilized as a potential immune-stimulatory agent | ||
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