논문 (학술지)
Coffee consumption promotes skeletal muscle hypertrophy and myoblast differentiation
| 등록번호 | RPMS-2019-0190759432 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Jang Y.; Son H.; Kim J. S.; Jung C.; Ahn J.; Hur J.; Ha T. | ||
| 논문구분 | 국외전문학술지 | 학술지명 | FOOD & FUNCTION |
| ISSN | 2042-6496 | 학술지 출판일자 | - |
| 학술지 볼륨번호 | 9 | 논문페이지 | 1102 ~ 1111 |
| 학술지 임팩트팩터 | 3.289 | 기여율 | 100 % |
| DOI | 10.1039/c7fo01683b | ||
| 초록 | Coffee is a widely consumed beverage worldwide and is believed to help prevent the occurrence of various chronic diseases. However, the effect of coffee on skeletal muscle hypertrophy, differentiation and the mechanisms of action responsible have remained unclear. To investigate the effect of coffee on skeletal muscle hypertrophy, mice were fed a normal diet or a normal diet supplemented with 0.3% coffee or 1% coffee. Coffee supplementation was observed to increase skeletal muscle hypertrophy, while simultaneously upregulating protein expression of total MHC, MHC2A, and MHC2B in quadricep muscle. Myostatin expression was also attenuated, and IGF1 was upregulated with subsequent phosphorylation of Akt and mTOR, while AMPK phosphorylation was attenuated. Coffee also increased the grip strength and PGC-1α protein expression, and decreased the expressions of TGF-β and myostatin in tricep muscle. Coffee activated the MKK3/6-p38 pathway and upregulated PGC-1α, which may play a role in promoting myogenic differentiation and myogenin expression in C2C12 cells. These results suggest that coffee increases skeletal muscle function and hypertrophy by regulating the TGF-β/myostatin - Akt - mTORC1. | ||
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