논문 (학술지)
Novel (1E, 3E, 5E)-1,6-bis(Substituted phenyl) hexa-1,3,5-triene Analogs Inhibit Melanogenesis in B16F10 Cells and Zebrafish
| 등록번호 | RPMS-2019-0190767983 | SCI 구분
?
※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Oh Jisun; Kim Jungeun; Jang Jin; Lee Sangwoo; Park Chul; Kim Woo-Keun; Kim Jong-Sang | ||
| 논문구분 | 국외전문학술지 | 학술지명 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
| ISSN | 1661-6596 | 학술지 출판일자 | 2018-04-03 |
| 학술지 볼륨번호 | 19 | 논문페이지 | 1067 ~ - |
| 학술지 임팩트팩터 | 3.69 | 기여율 | 0 % |
| DOI | 10.3390/ijms19041067 | ||
| 초록 | The present study aimed to evaluate the anti-melanogenic activity of 1,6-diphenyl-1,3,5-hexatriene and its derivatives in B16F10 murine melanoma cells and zebrafish embryos. Twenty five (1E,3E,5E)-1,6-bis(substituted phenyl)hexa-1,3,5-triene analogs were synthesized and their non-cytotoxic effects were predictively analyzed using three-dimensional quantitative structure-activity relationship approach. Inhibitory activities of these synthetic compounds against melanin synthesis were determined by evaluating melanin content and melanogenic regulatory enzyme expression in B16F10 cells. The anti-melanogenic activity was verified by observing body pigmentation in zebrafishes treated with these compounds. Compound #2, #4, and #6 effectively decreased melanogenesis induced by α-melanocyte-stimulating hormone. In particular, compound #2 remarkably lowered the mRNA and protein expression levels of microphthalmia-associated transcription factor (MITF), tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and TYRP2 in B16F10 cells and substantially reduced skin pigmentation in the developed larvae of zebrafish. These findings suggest that compound #2 may be used as an anti-melanogenic agent for cosmetic purpose | ||
연구개발성과 등록 또는 활용에 대한 문의는 논문 연구개발성과 담당자를 통해 문의하시기 바랍니다.
[문의] 한국과학기술정보연구원 Tel : 042)716-7066, https://curation.kisti.re.kr/
- NTIS 관련 이용문의는 NTIS 콜센터(042-869-1115)로 문의하시기 바랍니다.
NTIS의 논문 정보는 국가연구개발사업 수행을 통해 발생된 성과로, 조사분석 등을 통해 입력된 정보를 수집 및 제공하고 있어, 출판사 또는 논문 정보 제공 사이트(Scienceon, RISS 등)에서 일괄 제공하는 논문 정보와 차이가 있을 수 있습니다.