논문 (학술지)
Effect of green tea on hepatic lipid metabolism in mice fed a high-fat diet
| 등록번호 | RPMS-2018-0190599236 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Nam Miso; Choi Myung-Sook; Choi Ji-Young; Kim Nami; Kim Min-Sun; Jung Sunhee; Kim Juyeon; Ryu Do Hyun; Hwang Geum-Sook | ||
| 논문구분 | 국외전문학술지 | 학술지명 | JOURNAL OF NUTRITIONAL BIOCHEMISTRY |
| ISSN | 0955-2863 | 학술지 출판일자 | 2018-01-01 |
| 학술지 볼륨번호 | 51 | 논문페이지 | 1 ~ 7 |
| 학술지 임팩트팩터 | 4.41 | 기여율 | 0 % |
| 초록 | Green tea (GT) is a widely consumed beverage with health benefits, including antiobesity effects; however, the efficacy of GT on lipid levels associated with obesity is not clearly understood. Here, we examined the impact of GT consumption on lipid metabolism in the livers of high-fat diet (HFD)-induced obese mice. We performed lipid profiling using ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry in C57BL/6J mice fed a normal diet (ND), HFD and HFD with GT for 12 weeks. The partial least squares discriminant analysis score plot showed a difference among the groups and revealed that the levels of several lipid metabolites were altered in mice fed HFD with GT. The decreased levels of lysophospholipids (LPLs), such as lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine, in HFD mice compared to those of the ND group were recovered by supplementation of GT. In agreement with these lipid metabolites changes, hepatic lysophosphatidylcholine acyltransferase 2/4 was significantly increased in HFD mice. This study showed abnormal changes in lipid species associated with obesity, and these levels were attenuated by GT intake, suggesting a relationship between the reduction of hepatic LPL levels and inflammation in obesity. | ||
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