논문 (학술지)
Loss of DJ-1 promotes browning of white adipose tissue in diet-induced obese mice
| 등록번호 | RPMS-2019-0190785034 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Silvester Allwin Jennifa; Aseer Kanikkai Raja; Jang Hyun-Jun; Ryu Ri; Kwon Eun-Young; Park Jae Gyu; Cho Kiu-Hyung; Chaudhari Harmesh N.; Choi Myung-Sook; Suh Pann-Ghill; Yun Jong Won | ||
| 논문구분 | 국외전문학술지 | 학술지명 | JOURNAL OF NUTRITIONAL BIOCHEMISTRY |
| ISSN | 0955-2863 | 학술지 출판일자 | 2018-11-01 |
| 학술지 볼륨번호 | 61 | 논문페이지 | 56 ~ 67 |
| 학술지 임팩트팩터 | 4.41 | 기여율 | 0 % |
| 초록 | The seminal discovery of browning of white adipose tissue (WAT) holds great promise for the treatment of obesity and metabolic syndrome. DJ-1 is evolutionarily conserved across species, and mutations in DJ-1 have been identified in Parkinson's disease. Higher levels of DJ-1 are associated with obesity, but the underlying mechanism is less understood. Here, we report the previously unappreciated role of DJ-1 in white adipocyte biology in mature models of obesity. We used DJ-1 knockout (KO) mouse models and wild-type littermates maintained on a normal diet or high-fat diet as well as in vitro cell models to show the direct effects of DJ-1 depletion on adipocyte phenotype, thermogenic capacity, fat metabolism, and microenvironment profile. Global DJ-1 KO mice show increased sympathetic input to WAT and β3-adrenergic receptor intracellular signaling, leading to a previously unrecognized compensatory mechanism through browning of WAT with associated characteristics, including high mitochondrial contents, reduced lipid accumulation, adequate vascularization and attenuated autophagy. DJ-1 KO mice had normal body weight, energy balance, and adiposity, which were associated with protective effects on healthy WAT expansion by hyperplasia. Our findings revealed that browning of inguinal WAT occurred in DJ-1 KO mice that do not show increased predisposition to obesity and suggest that such potential mechanism may overcome the adverse metabolic consequences of obesity independent of an effect on body weight. Here, we provide the first direct evidence that targeting DJ-1 in adipocyte metabolic health may offer a unique therapeutic strategy for the treatment of obesity. | ||
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