논문 (학술지)
Role of Synbiotics Containing D-Allulose in the Alteration of Body Fat and Hepatic Lipids in Diet-Induced Obese Mice
| 등록번호 | RPMS-2019-0190727264 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Choi Bo-Ra; Kwon Eun-Young; Kim Hye-Jin; Choi Myung-Sook | ||
| 논문구분 | 국외전문학술지 | 학술지명 | NUTRIENTS |
| ISSN | 2072-6643 | 학술지 출판일자 | 2018-11-01 |
| 학술지 볼륨번호 | 10 | 논문페이지 | 1797 ~ - |
| 학술지 임팩트팩터 | 4.2 | 기여율 | 0 % |
| DOI | 10.3390/nu10111797 | ||
| 초록 | The effects of allulose and two probiotic species on diet-induced obese (DIO) mice were investigated. Lactobacillus sakei LS03 (10⁸ cfu/day) and Leuconostoc kimchii GJ2 (10⁸ cfu/day) were used as probiotics, and allulose (AL) as a prebiotic. The synergistic effect of prebiotics and probiotics in improving obesity was evaluated. Orally fed Lactobacillus sakei LS03 (LS) or Leuconostoc kimchii GJ2 (GJ), significantly decreased hepatic triglyceride (TG) and fatty acid (FA) compared to the high-fat diet (HFD) control. AL markedly decreased visceral adiposity and pro-inflammatory adipokines (leptin and resistin) and cytokines (IL-6 and IL-1β) as well as hepatic TG and FA. In addition, AL exerted synergic effects with probiotics (LS and/or GJ) on the reduction of visceral white adipose tissue (WAT), associated with a decreased leptin: adiponectin ratio. There was no significant differences between the AL-SL and AL group, allulose and GJ combination (AL-GJ) was more effective than allulose in improving dyslipidemia, and decreasing WAT weight and hepatic FA, suggesting allulose may act as a favorable prebiotic for GJ supplement than LS. Combination of allulose with LS and GJ supplementation (AL-LSGJ) was the most effective for improving obesity related complications among the synbiotics groups containing allulose. In conclusion, this study demonstrated that the synbiotic mixture with allulose was more effective in suppressing diet-induced obese (DIO) and its complications via the regulation of lipid metabolism, than the probiotics or allulose alone, suggesting allulose may act as a prebiotic for the two probiotics tested in the study. This new synbiotic mixture with allulose may help ameliorate the deleterious effects of diet-induced obesity and contribute to the growth of the food industry. | ||
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