논문 (학술지)
Microbial Synthesis of Non-Natural Anthraquinone Glucosides Displaying Superior Antiproliferative Properties
| 등록번호 | RPMS-2019-0190757812 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Nguyen Trang; Pandey Ramesh; Parajuli Prakash; Han Jang; Jung Hye; Park Yong; Sohng Jae | ||
| 논문구분 | 국외전문학술지 | 학술지명 | MOLECULES |
| ISSN | 1420-3049 | 학술지 출판일자 | 2018-08-28 |
| 학술지 볼륨번호 | 23 | 논문페이지 | 2171 ~ - |
| 학술지 임팩트팩터 | 3.1 | 기여율 | 0 % |
| DOI | 10.3390/molecules23092171 | ||
| 초록 | Anthraquinones, naturally occurring bioactive compounds, have been reported to exhibit various biological activities, including anti-inflammatory, antiviral, antimicrobial, and anticancer effects. In this study, we biotransformed three selected anthraquinones into their novel O-glucoside derivatives, expressing a versatile glycosyltransferase (YjiC) from Bacillus licheniformis DSM 13 in Escherichia coli. Anthraflavic acid, alizarin, and 2-amino-3-hydroxyanthraquinone were exogenously fed to recombinant E. coli as substrate for biotransformation. The products anthraflavic acid-O-glucoside, alizarin 2-O-β-d-glucoside, and 2-amino-3-O-glucosyl anthraquinone produced in the culture broths were characterized by various chromatographic and spectroscopic analyses. The comparative anti-proliferative assay against various cancer cells (gastric cancer-AGS, uterine cervical cancer-HeLa, and liver cancer-HepG2) were remarkable, since the synthesized glucoside compounds showed more than 60% of cell growth inhibition at concentrations ranging from ~50 μM to 100 μM. Importantly, one of the synthesized glucoside derivatives, alizarin 2-O-glucoside inhibited more than 90% of cell growth in all the cancer cell lines tested | ||
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