논문 (학술지)
Innate-like Cytotoxic Function of Bystander-Activated CD8(+) T Cells Is Associated with Liver Injury in Acute Hepatitis A
| 등록번호 | RPMS-2019-0190789339 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Kim Jihye; Chang Dong-Yeop; Lee Hyun Woong; Lee Hoyoung; Kim Jong Hoon; Sung Pil Soo; Kim Kyung Hwan; Hong Seon-Hui; Kang Wonseok; Lee Jino; Shin So Youn; Yu Hee Tae; You Sooseong; Choi Yoon Seok; Oh Insoo; Lee Dong Ho; Lee Dong Hyeon; Jung Min Kyung; Suh Kyung-Suk; Hwang Shin; Kim Won; Park Su-Hyung; Kim Hyung Joon; Shin Eui-Cheol | ||
| 논문구분 | 국외전문학술지 | 학술지명 | IMMUNITY |
| ISSN | 1074-7613 | 학술지 출판일자 | 2018-01-16 |
| 학술지 볼륨번호 | 48 | 논문페이지 | 161 ~ 173.e5 |
| 학술지 임팩트팩터 | 19.73 | 기여율 | 100 % |
| DOI | 10.1016/j.immuni.2017.11.025 | ||
| 초록 | Acute hepatitis A (AHA) involves severe CD8+ T cell-mediated liver injury. Here we showed during AHA, CD8+ T cells specific to unrelated viruses became activated. Hepatitis A virus (HAV)-infected cells produced IL-15 that induced T cell receptor (TCR)-independent activation of memory CD8+ T cells. TCR-independent activation of non-HAV-specific CD8+ T cells were detected in patients, as indicated by NKG2D upregulation, a marker of TCR-independent T cell activation by IL-15. CD8+ T cells derived from AHA patients exerted innate-like cytotoxicity triggered by activating receptors NKG2D and NKp30 without TCR engagement. We demonstrated that the severity of liver injury in AHA patients correlated with the activation of HAV-unrelated virus-specific CD8+ T cells and the innate-like cytolytic activity of CD8+ T cells, but not the activation of HAV-specific T cells. Thus, host injury in AHA is associated with innate-like cytotoxicity of bystander-activated CD8+ T cells, a result with implications for acute viral diseases. | ||
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