논문 (학술지)
Imatinib mesylate elicits extracellular signal-related kinase (ERK) activation and enhances the survival of gamma-irradiated epithelial cells
| 등록번호 | RPMS-2019-0190803578 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Lee Jeeyong; Ko Jiwon; Kim Hyun-Ji; Im Hyuntaik; Kim Eun Ju; Yi Jae Youn | ||
| 논문구분 | 국외전문학술지 | 학술지명 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS |
| ISSN | 0006-291X | 학술지 출판일자 | - |
| 학술지 볼륨번호 | 506 | 논문페이지 | 939 ~ 943 |
| 학술지 임팩트팩터 | 0.0 | 기여율 | 50 % |
| DOI | 10.1016/j.bbrc.2018.10.095 | ||
| 초록 |
Abstract
Imatinib mesylate, commercially known as Gleevec/Glivec, is the first targeted anticancer drug that inhibits activity of the tyrosine kinases, c-ABL, c-KIT, and PDGFR. A number of studies have shown that treatment with imatinib mesylate elicits extracellular signal-related kinase (ERK) activation, which, in turn, has been shown to confer radioresistance. Here, we investigated whether treatment with imatinib mesylate protects skin-derived epithelial cells, including normal keratinocytes, immortalized HaCaT and A431 cancer cell lines, from the effects of γ-radiation. ERK activation was detected 30 min after imatinib mesylate treatment in all three cell lines. In cells exposed to γ-irradiation in the presence of imatinib mesylate, this activation of ERK was associated with a reduction in radiation-induced apoptosis and enhanced cell survival. Similar effects of imatinib mesylate treatment were observed following γ-irradiation of a three-dimensional human skin culture system that reproduces a fully differentiated epithelium. Collectively, our findings provide the evidence of a protective effect of imatinib mesylate against the effects of γ-irradiation on epithelial-derived cells, regardless of their malignancy status.
Highlights
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