논문 (학술지)
Aruncus dioicus var. kamtschaticus extract suppresses mitochondrial apoptosis induced-neurodegeneration in trimethyltin injected ICR mice
| 등록번호 | RPMS-2019-0190774384 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Park Su Bin; Kang Jin Yong; Kim Jong Min; Park Seon Kyeong; Park Sang Hyun; Kang Jeong Eun; Lee Chang Jun; Kwon Bong Seok; Yoo Seul Ki; Lee Uk; Ok; Heo Ho Jin | ||
| 논문구분 | 국외전문학술지 | 학술지명 | JOURNAL OF FOOD BIOCHEMISTRY |
| ISSN | 0145-8884 | 학술지 출판일자 | 2018-08-15 |
| 학술지 볼륨번호 | 42 | 논문페이지 | 0 ~ 14 |
| 학술지 임팩트팩터 | 1.552 | 기여율 | 50 % |
| DOI | 10.1111/jfbc.12667 | ||
| 초록 | In the present study, we attempt to confirm the effect of the ethyl acetate fraction from Aruncus dioicus var. kamtschaticus (EFAD) against neurodegeneration with vari‐ous experiments using trimethyltin (TMT). First, learning and memory deterioration caused by TMT was examined with several behavioral tests. EFAD had an improve‐ment effect on TMT‐induced cognitive dysfunction. Second, to assess the oxidative stress caused by TMT, a series of biochemical indicators of the cholinergic and anti‐oxidant system were measured. EFAD showed superb effects on the recovery of the cholinergic system and reduction of oxidative stress. Third, to identify the mitochon‐drial apoptosis caused by TMT, mitochondrial activity and mitochondrial apoptotic signaling molecules were analyzed. EFAD improved mitochondrial activity and sup‐pressed mitochondrial apoptosis. Finally, dicaffeoylglucose isomers were identified as main compounds of EFAD with ultra‐performance liquid‐quadrupole‐time‐of flight mass spectrometry (UPLC‐QTOF/MS2). Consequently, EFAD showed a protective ef‐fect against mitochondrial apoptosis‐induced neurodegeneration in TMT‐injected mice based on antioxidant ability | ||
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