논문 (학술지)
Ligularia fischeri: A boon to diabetic cognitive deficits by protecting neuronal apoptosis via insulin signaling pathway
| 등록번호 | - | SCI 구분
?
※구분 : SCI(SCIE포함), 비SCI |
비SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Sang Hyun Park; Seon Kyeong Park; Jin Yong Kang; Jong Min Kim; Jeong Eun Kang; Chang Jun Lee; Bong Seok Kwon; Su Bin Park; Dae Ok Kim; Ho Jin Heo | ||
| 논문구분 | 국외전문학술지 | 학술지명 | Transylvanian Review |
| ISSN | 1221-1249 | 학술지 출판일자 | 2018-09-20 |
| 학술지 볼륨번호 | 26 | 논문페이지 | 7269 ~ 7279 |
| 학술지 임팩트팩터 | 0.0 | 기여율 | 100 % |
| 초록 | This study investigated the effect of ethyl acetate fraction from Ligularia fischeri(EFLF) on learning and memorydeficits and potential mechanisms involved in diabetic mice. The diabetic mice were induced by injecting STZ (60 mg/kg of body weight) dissolved in sodium citrate buffer (0.1 M, pH 4.5) once a day for 2 consecutive days in the abdominal cavity.Then diabetic mice were orally administered EFLF for 4 weeks and then their diabetes and improving effect on cognitive function was evaluated.In addition,the changes of oxidative damage and protein expression, related in insulin signaling pathway, in brain were examined. Administration of EFLF (100 and 200 mg/kg of body weight) remarkably improved high glucose states and improved learning and memory deficits, as confirmed through the Y-maze, passive avoidance, and Morris water maze (MWM) tests. Moreover,diabetic mice showed elevation of acetylcholinesterase (AChE) activity, reduction of acetylcholine (ACh) content, elevation of malondialdehyde (MDA), and decreased superoxide dismutase (SOD) in brain tissue. However, administration of EFLF significantly improved these changes. In the analysis of protein, EFLF treatment significantly increased brain-derived neurotrophic factor (BDNF) expression and AMP-activated protein kinase (AMPK) phosphorylation, enhanced the insulin signaling pathway, and inhibited themitochondrial apoptotic signaling pathway. Finally, quercetin-3-O-galactoside, 3,4-O-dicaffeoylquinic acid, and 3,5-O-dicaffeoylquinic acid and acetylated quercetin of 3-O-galactoside as phenolic compounds of EFLF were identified using a UPLC-QTOF/MS system. In conclusion, the results suggest that EFLF improves cognitive function in streptozotocin (STZ) | ||
연구개발성과 등록 또는 활용에 대한 문의는 논문 연구개발성과 담당자를 통해 문의하시기 바랍니다.
[문의] 한국과학기술정보연구원 Tel : 042)716-7066, https://curation.kisti.re.kr/
- NTIS 관련 이용문의는 NTIS 콜센터(042-869-1115)로 문의하시기 바랍니다.
NTIS의 논문 정보는 국가연구개발사업 수행을 통해 발생된 성과로, 조사분석 등을 통해 입력된 정보를 수집 및 제공하고 있어, 출판사 또는 논문 정보 제공 사이트(Scienceon, RISS 등)에서 일괄 제공하는 논문 정보와 차이가 있을 수 있습니다.