논문 (학술지)
Effects of Rubus coreanus byproducts on intestinal microbiota and the immune modulation
| 등록번호 | RPMS-2018-0190637193 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Yu Da Yoon; Kim Sung Hak; Kim Jeong A; Kim In Sung; Moon Yang Soo; Lee Sang Suk; Park Hwa Chun; Jung Jong Hyun; Chung Yi Hyung; Shin Dae Keun; Nam Ki Chang; Choi In Soon; Cho Kwang Keun | ||
| 논문구분 | 국외전문학술지 | 학술지명 | ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES |
| ISSN | 1011-2367 | 학술지 출판일자 | 2018-03-01 |
| 학술지 볼륨번호 | 31 | 논문페이지 | 429 ~ 438 |
| 학술지 임팩트팩터 | 1.243 | 기여율 | 100 % |
| DOI | 10.5713/ajas.17.0733 | ||
| 초록 | Objective: Although the efficacy of Rubus coreanus (RC) byproducts as a feed additive has been recognized, its effects on intestinal microorganisms and the immune system are still unknown. Methods: Six-week-old male rats were treated with 0.5% RC (T1), 1.0% RC (T2), and 1.5% RC (T3) for 4 weeks. Results: We found that treatment with RC byproducts significantly increased the daily gain of body weight and feed intake. Treg-cell differentiation was enhanced in the mesenteric lymph nodes and spleen from the rats fed with RC byproducts. Illumina sequencing showed that bacteria in the phylum Firmicutes decreased and while those in the phylum Bacteroidetes increased in RC-treated groups. Particularly, the pathogenic microorganisms in the family Peptococcaceae decreased, and the non-pathogenic families Lachnospiraceae and S24-7 increased. Quantitative polymerase chain reaction analysis showed that the RC byproducts increased the lactic acid bacteria Bifidobacterium spp., Oscillospira spp., Leuconostoc citreum, and Weissella cibaria in a concentration-dependent manner. Conclusion: RC byproducts may be effective in immunomodulation by affecting intestinal microorganisms. | ||
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