논문 (학술지)
Polydopamine-mediated surface modifications of poly L-lactic acid with hydroxyapatite, heparin and bone morphogenetic protein-2 and their effects on osseointegration
| 등록번호 | RPMS-2019-0090703264 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Yun Young Jin; Kim Han-Jun; Lee Deok-Won; Um Sewook; Chun Heung Jae | ||
| 논문구분 | 국내전문학술지 | 학술지명 | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY |
| ISSN | 1226-086X | 학술지 출판일자 | 2018-11-25 |
| 학술지 볼륨번호 | 67 | 논문페이지 | 244 ~ 254 |
| 학술지 임팩트팩터 | 0.0 | 기여율 | 100 % |
| 초록 | Abstract Surface modified poly L -lactic acid (PLLA) samples with hydroxyapatite (HA), heparin and bone morphogenetic protein-2 (BMP-2) mediated by polydopamine (pDA) coating (PLLA/pDA/HA/Hep/BMP-2) were prepared, and their effects on the enhancements of bone formation and osseointegration were evaluated in vitro and in vivo as compared to PLLA, PLLA/pDA/HA, and PLLA/pDA/Hep/BMP-2. The changes in surface chemical compositions, morphologies and wettabilities were observed by X-ray photoelectron spectroscopy (XPS), field-emission scanning electron microscopy (FE-SEM), atomic force microscopy (AFM) and water contact angle measurements. Pre-coating of HA particles with pDA provided uniform and homogeneous anchoring of particles to PLLA surface. In addition, the strong ionic interaction between heparin and pDA led PLLA surface readily heparinized for loading of BMP-2. In vitro experiments revealed that the levels of alkaline phosphatase (ALP) activity, calcium deposition, and osteocalcin (OCN) gene expression were higher in MG-63 human osteosarcoma cell lines grown on PLLA/pDA/HA/Hep/BMP-2 than on control PLLA, PLLA/pDA/HA, and PLLA/pDA/Hep/BMP-2. In vivo studies using micro-computed tomography (micro-CT) also showed that PLLA/pDA/HA/Hep/BMP-2 screw exhibited greatest value of bone volume (BV) and bone volume/tissue volume (BV/TV) among samples. Histological evaluations with H&E and Von Kossa staining demonstrated that a combination of HA and BMP-2 contributed to the strong osseointegration. Graphical abstract [DISPLAY OMISSION] | ||
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