논문 (학술지)
Antidepressant Effects of Vaccinium bracteatum via Protection Against Hydrogen Peroxide-Induced Oxidative Stress and Apoptosis
| 등록번호 | RPMS-2019-0190717504 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Oh Dool-Ri; Kim Yujin; Choi Eun-Jin; Jo Ara; Shin Jawon; Kang Huwon; Lee Seul-Gi; Kim Jaeyong; Kim Young Ran; Choi Chul Yung | ||
| 논문구분 | 국외전문학술지 | 학술지명 | AMERICAN JOURNAL OF CHINESE MEDICINE |
| ISSN | 0192-415X | 학술지 출판일자 | 2018-01-01 |
| 학술지 볼륨번호 | 46 | 논문페이지 | 1499 ~ 1518 |
| 학술지 임팩트팩터 | 0.0 | 기여율 | 100 % |
| DOI | 10.1142/S0192415X18500775 | ||
| 초록 | The present study evaluates the anti-oxidative stress activity of Vaccinium bracteatum Thunb. fruit extract (VBFW) to identify the mechanisms responsible for its antidepressant-like effects. To evaluate the antidepressant and anti-oxidant effects of VBFW, malondialdehyde (MDA), serotonin transporter (SERT), and monoamine oxidase A (MAO-A) levels were measured in a mouse model of chronic restraint stress (CRS). The underlying mechanisms preventing oxidative stress and neuronal apoptosis were investigated using in vitro models of hydrogen peroxide (H2O2 thorn-induced neuronal damage. The results showed that VBFW treatment (200 mg/kg) significantly reduced MDA, SERT, and MAO-A levels in the prefrontal cortex of CRS mice. Furthermore, VBFW (30 mu g/mL) exhibited protective effects against H2O2-induced cell death via inhibition of the H2O2-induced increase in Bax and decrease in Bcl-2 levels within the mitochondria of SH-SY5Y cells. Furthermore, VBFW (10 and 30 mu g/mL) exerted protective effects against H2O2-induced cell death through inhibition of key mitochondria-associated apoptotic proteins such as cytochrome c, caspase-3 and PARP. Additionally, VBFW (10 and 30 mu g/mL) could improve the activity of anti-oxidant enzymes (such as SOD and catalase) in H2O2-treated SH-SY5Y cells. These results suggest that the antidepressant and anti-oxidant effects of VBFW might be mediated by the regulation of | ||
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