논문 (학술지)
The Effects of the 3-OH Group of Kaempferol on Interfollicular Epidermal Stem Cell Fate
| 등록번호 | RPMS-2019-0090742223 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Chae Je Byeong; Choi Hye-Ryung; Shin Jung-Won; Na Jung-Im; Huh Chang-Hun; Park Kyoung-Chan | ||
| 논문구분 | 국내전문학술지 | 학술지명 | ANNALS OF DERMATOLOGY |
| ISSN | 1013-9087 | 학술지 출판일자 | 2018-12-01 |
| 학술지 볼륨번호 | 30 | 논문페이지 | 694 ~ 700 |
| 학술지 임팩트팩터 | 1.86 | 기여율 | 100 % |
| 초록 | Background: Kaempferol (3,4’,5,7-tetrahydroxyflavone) is a flavonoid known to have a wide range of pharmacological activities. The 3-OH group in flavonoids has been reported to determine antioxidant activities. Objective: We testedwhether kaempferol can affect the expression of integrins and the stem cell fate of interfollicular epidermal stem cells. Methods: Skin equivalent (SE) models were constructed, and the expression levels of stem cell markers and basement membrane-related antigens were tested. The immunohistochemical staining patterns of integrins, p63, and proliferating cell nuclear antigen (PCNA) were compared between kaempferol- and apigenin-treated SE models. Reverse transcription-polymerase chain reaction (RT-PCR) was used to evaluate the mRNA expression of integrins. Results: Kaempferol increased the thickness of the epidermis when added to prepare SEs. In addition, the basal cells of kaempferol-treated SEs appeared more columnar. In the immunohistological study, the expression of integrins α6 and β1 and the numbers of p63- and PCNA-positive cells were markedly higher in the kaempferol-treated model. However, apigenin showed no effects on the formation of three-dimensional skin models. RT-PCR analysis also confirmed that kaempferol increased the expression of integrin α6 and integrin β1. Conclusion: Our findings indicated that kaempferol can increase the proliferative potential of basal epidermal cells by modulating the basement membrane. In other words, kaempferol can affect the fate of interfollicular epidermal stem cells by increasing the expression of both integrins α6 and β1. These effects, in particular, might be ascribed to the 3-OH group of kaempferol. | ||
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