논문 (학술지)
Effect of beta-Blockers Beyond 3Years After Acute Myocardial Infarction
| 등록번호 | RPMS-2019-0190715516 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Park Jin Joo; Seok; Youn Tae‐Jin; Chae In‐Ho; Choi Dong‐Ju | ||
| 논문구분 | 국외전문학술지 | 학술지명 | JOURNAL OF THE AMERICAN HEART ASSOCIATION |
| ISSN | 2047-9980 | 학술지 출판일자 | 2018-01-01 |
| 학술지 볼륨번호 | 7 | 논문페이지 | e007567 ~ - |
| 학술지 임팩트팩터 | 0.0 | 기여율 | 50 % |
| DOI | 10.1161/JAHA.117.007567 | ||
| 초록 | Background The optimal duration of β‐blocker therapy in patients with acute myocardial infarction (AMI) is unknown. We aimed to evaluate the late effect of β‐blockers in patients with AMI. Methods and Results We enrolled all consecutive patients who presented with AMI at Seoul National University Bundang Hospital, between June 3, 2003 and February 24, 2015. The primary end point was 5‐year all‐cause mortality, depending on the use of β‐blockers at discharge, 1 year after AMI, and 3 years after AMI. Of 2592 patients, the prescription rates of β‐blockers were 72%, 69%, 63%, and 60% at discharge and 1, 3, and 5 years after AMI, respectively. The patients who were receiving β‐blocker therapy had more favorable clinical characteristics, such as younger age (62 versus 65 years; P <0.001). They received reperfusion therapy more often (92% versus 80%; P <0.001) than those without β‐blocker prescription. In the univariate analysis, the patients with β‐blocker prescription had lower 5‐year mortality at all time points. In the Cox model after adjustment for significant covariates, β‐blocker prescription at discharge was associated with a 29% reduced mortality risk (hazard ratio, 0.71; 95% confidence interval, 0.55–0.90; P = 0.006); however, β‐blocker prescriptions at 1 and 3 years after AMI were not associated with reduced mortality. Conclusions The beneficial effect of β‐blocker therapy after AMI may be limited until 1 year after AMI. Whether late β‐blocker therapy beyond 1 year after AMI offers clinical benefits should be confirmed in further clinical trials. | ||
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