논문 (학술지)
Gata6 in pluripotent stem cells enhance the potential to differentiate into cardiomyocytes
| 등록번호 | RPMS-2019-0090744697 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Yoon Chang-Hwan; Kim Tae-Won; Koh Seok-Jin; Choi Young-Eun; Hur Jin; Kwon Yoo-Wook; Cho Hyun-Jai; Kim Hyo-Soo | ||
| 논문구분 | 국내전문학술지 | 학술지명 | BMB REPORTS |
| ISSN | 1976-6696 | 학술지 출판일자 | 2018-01-01 |
| 학술지 볼륨번호 | 51 | 논문페이지 | 85 ~ 91 |
| 학술지 임팩트팩터 | 0.0 | 기여율 | 100 % |
| DOI | 10.5483/BMBRep.2018.51.2.176 | ||
| 초록 | Pluripotent stem cell (PSC) variations can cause significant differences in the efficiency of cardiac differentiation. This process is unpredictable, as there is not an adequate indicator at the undifferentiated stage of the PSCs. We compared global gene expression profiles of two PSCs showing significant differences in cardiac differentiation potential. We identified 12 up-regulated genes related to heart development, and we found that 4 genes interacted with multiple genes. Among these genes, Gata6 is the only gene that was significantly induced at the early stage of differentiation of PSCs to cardiomyocytes. Gata6 knock-down in PSCs decreased the efficiency of cardiomyocyte production. In addition, we analyzed 6 mESC lines and 3 iPSC lines and confirmed that a positive correlation exists between Gata6 levels and efficiency of differentiation into cardiomyocytes. In conclusion, Gata6 could be utilized as a biomarker to select the best PSC lines to produce PSC-derived cardiomyocytes for therapeutic purposes. | ||
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