논문 (학술지)
A Nomogram for Predicting Amyloid PET Positivity in Amnestic Mild Cognitive Impairment
| 등록번호 | RPMS-2019-0190746935 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Kim Si Eun; Woo Sook-Young; Kim Seon Woo; Chin Juhee; Kim Hee Jin; Lee Byung In; Park JinSe; Park Kyung Won; Noh Young; Ye Byoung Seok; Yoo Han Soo; San Lee Jin; Kim Yeshin; Kim Seung Joo; Cho Soo Hyun; Na Duk L.; Lockhart Samuel N.; Jang Hyemin; Seo Sang Won | ||
| 논문구분 | 국외전문학술지 | 학술지명 | JOURNAL OF ALZHEIMERS DISEASE |
| ISSN | 1387-2877 | 학술지 출판일자 | 2018-10-30 |
| 학술지 볼륨번호 | 14 | 논문페이지 | P1248 ~ 691 |
| 학술지 임팩트팩터 | 3.48 | 기여율 | 50 % |
| DOI | 10.3233/JAD-180048 | ||
| 초록 | Background: Most clinical trials focus on amyloid- positive (A +) amnestic mild cognitive impairment (aMCI), but screening failures are high because only a half of patients with aMCI are positive on A PET. Therefore, it becomes necessary for clinicians to predict which patients will have A biomarker. Objective:We aimed to compare clinical factors, neuropsychological (NP) profiles, and apolipoprotein E (APOE) genotype between A + aMCI and A – aMCI and to develop a clinically useful prediction model of A positivity on PET (PET-A +) in aMCI using a nomogram. Methods:We recruited 523 aMCI patients who underwent A PET imaging in a nation-wide multicenter cohort. The results of NP measures were divided into following subgroups: 1) Stage (Early and Late-stage), 2) Modality (Visual, Verbal, and Both), 3) Recognition failure, and 4) Multiplicity (Single and Multiple). A nomogram for PET-A + in aMCI patients was constructed using a logistic regression model. Results: PET-A + had significant associations with NP profiles for several items, including high Clinical Dementia Rating Scale Sum of Boxes score (OR 1.47, p = 0.013) and impaired memory modality (impaired both visual and verbal memories compared with visual only, OR 3.25, p = 0.001). Also, presence of APOE ε4 (OR 4.14, p < 0.001) was associated with PET-A +. These predictors were applied to develop the nomogram, which showed good prediction performance (C-statistics = 0.79). Its prediction performances were 0.77/0.74 in internal/external validation. Conclusions: The nomogram consisting of NP profiles, especially memory domain, and APOE ε4 genotype may provide a useful predictive model of PET-A + in patients with aMCI. | ||
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