논문 (학술지)
Distinct amyloid distribution patterns in amyloid positive subcortical vascular cognitive impairment
| 등록번호 | RPMS-2019-0190746983 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Jang Hyemin; Park Jong-Yun; Jang Young Kyoung; Kim Hee Jin; Lee Jin San; Na Duk L.; Noh Young; Lockhart Samuel N.; Seong Joon-Kyung; Seo Sang Won | ||
| 논문구분 | 국외전문학술지 | 학술지명 | SCIENTIFIC REPORTS |
| ISSN | 2045-2322 | 학술지 출판일자 | 2018-11-01 |
| 학술지 볼륨번호 | 8 | 논문페이지 | 16178 ~ 16178 |
| 학술지 임팩트팩터 | 4.12 | 기여율 | 33 % |
| DOI | 10.1038/s41598-018-34032-3 | ||
| 초록 | Amyloid-β (Aβ) and cerebral small vessel disease (CSVD) commonly coexist. They can occur independently by chance, or may interact with each other. We aimed to determine whether the distribution of Aβ in subcortical vascular cognitive impairments (SVCI) patients can be classified by the underlying pathobiologies. A total of 45 11C-Pittsburgh compound B PET positive (PiB(+)) SVCI patients were included in this study. They were classified using a new cluster analysis method which adopted the Louvain method, which finds optimal decomposition of the participants based on similarity of relative Aβ deposition pattern. We measured atherosclerotic cerebral small vessel disease (CSVD) markers and cerebral amyloid angiopathy (CAA) markers. Forty-five PiB(+) SVCI patients were classified into two groups: 17 patients with the characteristic Alzheimer’s disease like Aβ uptake with sparing of occipital region (OccSp) and 28 patients with occipital predominant Aβ uptake (OccP). Compared to OccSp group, OccP group had more postive association of atherosclerotic CSVD score (p for interaction = 0.044), but not CAA score with occipital/global ratio of PiB uptake. Our findings suggested that Aβ positive SVCI patients might consist of heterogeneous groups with combined CSVD and Aβ resulting from various pathobiologies. Furthermore, atherosclerotic CSVD might explain increased occipital Aβ uptakes. | ||
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