논문 (학술지)
Optimal Processing Conditions of Boswellia carteri Birdw. Using Response Surface Methodology
등록번호 | - | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
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저자명 (주·공동저자) | Yoon Jee-Hyun; 이금산; 윤지현; 김정훈; 주영승; 함성식; 강부연; 이승호; 최고야 ※ 과제 참여정보와 일치하는 연구자 상세정보로 정확하지 않을 수 있습니다. |
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논문구분 | 국외전문학술지 | 학술지명 | PHARMACOGNOSY MAGAZINE |
ISSN | 0973-1296 | 학술지 출판일자 | - |
학술지 볼륨번호 | 14 | 논문페이지 | 235 ~ 41 |
학술지 임팩트팩터 | 1.525 | 기여율 | 100 % |
DOI | 10.4103/pm.pm_140_17 | ||
초록 | Background: Boswellia carteri Bridw. is being widely used for its anti‑inflammatory properties, as well as for wound healing, antimicrobial, and immunomodulatory properties, and boswellic acids (BAs) are considered to be the main active constituents. Objectives: To investigate optimal conditions of stir‑baking process for the resin of B. carteri with vinegar of using response surface methodology (RSM). Materials and Methods: The concentration of acetic acid, heating temperature, and heating time were set as influential factors, and the yields of chemical compounds were the response values which were optimally designed by a Box–Behnken design. The amounts of 11-keto-β-boswellic acid (KBA) and α-boswellic acid (αBA) in B. carteri resin were quantified using high‑performance liquid chromatography analysis. Results: Maximum amounts of KBA and αBA in B. carteri resin were obtained using 6% acetic acid for 10 min at 90°C in preliminary test. Two factor interactions, such as acetic acid concentration–heating temperature and heating temperature–heating time, were significantly observed by multiple regression analysis. Optimal processing conditions from RSM were 5.83% for acetic acid concentration, 9.56 min for heating time, and 89.87°C for heating temperature. Under the modified conditions, the experimental value of the response was 11.25 mg/g, which was similar to the predicted value. Conclusions: The results suggest that the optimal conditions for the stir‑baking process of B. carteri resin were determined by RSM, which was reliable and applicable to practical processing of herbal medicine. |
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