논문 (학술지)
Genome sequencing and protein domain annotations of Korean Hanwoo cattle identify Hanwoo-specific immunity-related and other novel genes
| 등록번호 | RPMS-2018-0190689975 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Caetano-Anolles Kelsey; Kim Kwondo; Kwak Woori; Sung Samsun; Kim Heebal; Choi Bong-Hwan; Lim Dajeong | ||
| 논문구분 | 국외전문학술지 | 학술지명 | BMC GENETICS |
| ISSN | 1471-2156 | 학술지 출판일자 | 2018-05-29 |
| 학술지 볼륨번호 | 19 | 논문페이지 | ARTN37 ~ - |
| 학술지 임팩트팩터 | 2.266 | 기여율 | 100 % |
| DOI | 10.1186/s12863-018-0623-x | ||
| 초록 | information for potential use in evolutionary studies, medical applications, and breeding of selective traits. Here, we analyzed genomic data collected from 136 Korean Native cattle, known as Hanwoo, using advanced statistical methods. Results: Results revealed Hanwoo-specific protein domains which were largely characterized by immunoglobulin function. Furthermore, domain interactions of novel Hanwoo-specific genes reveal additional links to immunity. Novel Hanwoo-specific genes linked to muscle and other functions were identified, including protein domains with functions related to energy, fat storage, and muscle function that may provide insight into the mechanisms behind Hanwoo cattle’s uniquely high percentage of intramuscular fat and fat marbling. Conclusion: The identification of Hanwoo-specific genes linked to immunity are potentially useful for future medical research and selective breeding. The significant genomic variations identified here can crucially identify genetic novelties that are arising from useful adaptations. These results will allow future researchers to compare and classify breeds, identify important genetic markers, and develop breeding strategies to further improve significant traits. | ||
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