논문 (학술지)
Oxyresveratrol-induced DNA cleavage triggers apoptotic response in Candida albicans
| 등록번호 | RPMS-2019-0190728193 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Kim Suhyun; Lee Dong Gun | ||
| 논문구분 | 국외전문학술지 | 학술지명 | MICROBIOLOGY-SGM |
| ISSN | 1350-0872 | 학술지 출판일자 | - |
| 학술지 볼륨번호 | 164 | 논문페이지 | 1112 ~ 1121 |
| 학술지 임팩트팩터 | 2.151 | 기여율 | 100 % |
| DOI | 10.1099/mic.0.000696 | ||
| 초록 | Oxyresveratrol is a naturally occurring phytoalexin produced by plants in response to infection. Biological activities of oxyresveratrol have been studied such as antioxidant, anticancer and anti-inflammation. However, further antimicrobial activity and its mechanism need to be investigated. This study exhibited growth inhibition against pathogenic fungi and investigated its mode of action. Oxyresveratrol inflicted cleavage on DNA, leading to G2/M phase arrest. DNA damage by oxyresveratrol was not the result of oxidative stress but it was triggered by direct binding to DNA. Oxyresveratrol-treated cells showed an apoptotic pathway characterized by phosphatidylserine exposure, apoptotic volume decrease and metacaspase activation. Mitochondria-associated apoptotic features also appeared. Oxyresveratrol-induced Ca2+ overload led to mitochondrial membrane depolarization and release of cytochrome c from mitochondria to cytosol. In conclusion, oxyresveratrol with DNA-binding affinity induces DNA cleavage, and eventually leads to mitochondria-mediated apoptosis in Candida albicans. | ||
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