논문 (학술지)
A new synthetic drug 5-(2-aminopropyl)indole (5-IT) induces rewarding effects and increases dopamine D1 receptor and dopamine transporter mRNA levels
| 등록번호 | RPMS-2019-0190762019 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Botanas Chrislean Jun; a June Bryan; a Irene Joy; Kim Mikyung; Custodio Raly James; Woo Taeseon; Seo Joung-Wook; Jang Choon-Gon; Yang Ji Seul; Yoon Yoon Mi; Lee Yong Sup; Kim Hee Jin; Cheong Jae Hoon | ||
| 논문구분 | 국외전문학술지 | 학술지명 | BEHAVIOURAL BRAIN RESEARCH |
| ISSN | 0166-4328 | 학술지 출판일자 | 2018-04-02 |
| 학술지 볼륨번호 | 341 | 논문페이지 | 122 ~ 128 |
| 학술지 임팩트팩터 | 0.0 | 기여율 | 100 % |
| DOI | 10.1016/j.bbr.2017.12.026 | ||
| 초록 | Abstract In recent years, there has been a marked increase in the use of recreational synthetic psychoactive substances, which is a cause of concern among healthcare providers and legal authorities. In particular, there have been reports on the misuse of 5-(2-aminopropyl)indole (5-API; 5-IT), a new synthetic drug, and of fatal and non-fatal intoxication. Despite these reports, little is known about its psychopharmacological effects and abuse potential. Here, we investigated the abuse potential of 5-IT by evaluating its rewarding and reinforcing effects through conditioned place preference (CPP) (1, 10, and 30 mg/kg, i.p.) in mice and self-administration test (0.1, 0.3, 1, and 3 mg/kg/inf., i.v.) in rats. We also examined whether 5-IT (1, 3, and 10 mg/kg, i.p.) induces locomotor sensitization in mice following a 7-day treatment and drug challenge. Then, we explored the effects of 5-IT (10 mg/kg, i.p.) on dopamine-related genes in the striatum, prefrontal cortex (PFC), and substantia nigra pars compacta (SNc)/ventral tegmental (VTA) of mice by quantitative real-time polymerase chain reaction. 5-IT produced CPP in mice but was not reliably self-administered by rats. 5-IT also induced locomotor sensitization following repeated administration and drug challenge. Moreover, 5-IT increased mRNA levels of dopamine D1 receptor in the striatum and PFC and dopamine transporter in the SNc/VTA of mice. These results indicate that 5-IT has psychostimulant and rewarding properties, which may be attributed to its ability to affect the dopaminergic system in the brain. These findings suggest that 5-IT poses a substantial risk for abuse and addiction in humans. Highlights 5-IT is an indole and phenethylamine derivative. 5-IT induced conditioned place preference. 5-IT elicited locomotor sensitization in mice. Dopamine D1 receptor in mice striatum and PFC was increased by 5-IT. 5-IT has rewarding properties. | ||
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