논문 (학술지)
Anti-Inflammatory Effects of Streamed Platycodon grandiflorum against UVB Radiation-Induced Oxidative Stress in Human Primary Dermal Fibroblast
| 등록번호 | RPMS-2019-0090822174 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
비SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Lee Ji Yeon; Park Jeong-Yong; Lee Dae Young; Kim Hyung Don; Kim Geum-Soog; Lee Seung Eun; Seo Kyung Hye | ||
| 논문구분 | 국내전문학술지 | 학술지명 | 한국식품영양학회지 |
| ISSN | 1225-4339 | 학술지 출판일자 | - |
| 학술지 볼륨번호 | 31 | 논문페이지 | 495 ~ 501 |
| 학술지 임팩트팩터 | 0.5462 | 기여율 | 100 % |
| 초록 | Ultraviolet B (UVB) exposure is a risk factor for skin damage resulting in oxidative stress, inflammation, and cell death. The purpose of this study was to investigate the physicochemical properties of Platycodon grandiflorum (PG) to improve its biological activities using a three-step steaming process. We investigated the protective effects of PG and steamed PG extracts on human dermal fibroblasts (HDFs) against UVB radiation-induced oxidative stress and inflammation as well as the underlying mechanisms. The antioxidant potential of the PG extracts was evaluated by measuring the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) scavenging activity. ABTS and DPPH were shown by the 0, 30, and 70% ethanol extracts of 2S-PG and 3S-PG ( $IC_{50}$ , 28~45 and $27{\sim}30{\mu}g/mL$ , respectively). Treatment of UVB-irradiated cells with steamed PG ( $25{\sim}400{\mu}g/mL$ ) did not affect their viability. The streamed PG extract suppressed UVB-induced generation of reactive oxygen species (ROS). In addition, streamed PG extract reduced cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) protein expression in UVB-irradiated HDF, regulating nuclear factor $(NF)-{\kappa}B$ expression. These findings suggest that steamed PG extract may be potentially effective against inflammation associated with UVB-induced oxidation stress. | ||
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