논문 (학술지)
Germinated soy germ with increased soyasaponin Ab improves BMP-2-induced bone formation and protects against in vivo bone loss in osteoporosis
| 등록번호 | RPMS-2019-0190813759 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Choi Chan-Woong; Choi Sik-Won; Kim Han-Jun; Lee Kwang-Sik; Kim Shin-Hye; Kim Sun-Lim; Do Sun Hee; Seo Woo-Duck | ||
| 논문구분 | 국외전문학술지 | 학술지명 | SCIENTIFIC REPORTS |
| ISSN | 2045-2322 | 학술지 출판일자 | - |
| 학술지 볼륨번호 | 8 | 논문페이지 | 12970 ~ - |
| 학술지 임팩트팩터 | 4.259 | 기여율 | 100 % |
| DOI | 10.1038/s41598-018-31118-w | ||
| 초록 | Osteoporosis is frequently induced following menopause, and bone fractures result in serious problems including skeletal deformity, pain, and increased mortality. Therefore, safe and effective therapeutic agents are needed for osteoporosis. This study aimed to clarify the bone protecting effects of germinated soy germ extracts (GSGE) and their mode of action. GSGE increased expression of alkaline phosphatase (ALP) and osteocalcin (OCL) by stimulating the expression of runt-related transcription factor 2 (Runx2) and osterix (Osx) through activation of Smad signaling molecules. Furthermore, germination of soy germ increased levels of nutritional components, especially soyasaponin Ab. The anabolic activity of soyasaponin Ab in GSGE was also evaluated. GSGE and soyasaponin Ab significantly protected against ovariectomy (OVX)-induced bone loss and improved bone-specific alkaline phosphatase (BALP) level in mouse serum. These in vitro and in vivo study results demonstrated that GSGE and soyasaponin Ab have potential as therapeutic candidate agents for bone protection in postmenopausal osteoporosis. | ||
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