논문 (학술지)
Analysis of cross-population differentiation between Thoroughbred and Jeju horses
| 등록번호 | RPMS-2019-0090814573 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Lee Wonseok; Park Kyung-Do; Taye Mengistie; Lee Chul; Kim Heebal; Lee Hak-Kyo; Shin Donghyun | ||
| 논문구분 | 국외전문학술지 | 학술지명 | ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES |
| ISSN | 1011-2367 | 학술지 출판일자 | - |
| 학술지 볼륨번호 | 31 | 논문페이지 | 1110 ~ 1118 |
| 학술지 임팩트팩터 | 0.971 | 기여율 | 100 % |
| DOI | 10.5713/ajas.17.0460 | ||
| 초록 | This study was intended to identify genes positively selected in Thoroughbred horses (THBs) that potentially contribute to their running performances. Methods: The genomes of THB and Jeju horses (JH, Korean native horse) were compared to identify genes positively selected in THB. We performed cross-population extended haplotype homozygosity (XP-EHH) and cross-population composite likelihood ratio test (XP-CLR) statistical methods for our analysis using whole genome resequencing data of 14 THB and 6 JH. We identified 98 (XP-EHH) and 200 (XP-CLR) genes that are under positive selection in THB. Gene enrichment analysis identified 72 gene ontology biological process (GO BP) terms. The genes and GO BP terms explained some of THB's characteristics such as immunity, energy metabolism and eye size and function related to running performances. GO BP terms that play key roles in several cell signaling mechanisms, which affected ocular size and visual functions were identified. GO BP term Eye photoreceptor cell differentiation is among the terms annotated presumed to affect eye size. Conclusion: Our analysis revealed some positively selected candidate genes in THB related to their racing performances. The genes detected are related to the immunity, ocular size and function, and energy metabolism. | ||
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