논문 (학술지)
Leukocyte Immunoglobulin-Like Receptors A2 and A6 are Expressed in Avian Macrophages and Modulate Cytokine Production by Activating Multiple Signaling Pathways
| 등록번호 | RPMS-2019-0190725287 | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | Truong Anh; Rengaraj Deivendran; Hong Yeojin; Ha Thi Thanh Tran; Hoang Vu Dang; Viet Khong Nguyen; Lillehoj Hyun S.; Hong Yeong Ho | ||
| 논문구분 | 국외전문학술지 | 학술지명 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
| ISSN | 1422-0067 | 학술지 출판일자 | 2018-09-11 |
| 학술지 볼륨번호 | 19 | 논문페이지 | 2710 ~ 2710 |
| 학술지 임팩트팩터 | 3.226 | 기여율 | 100 % |
| DOI | 10.3390/ijms19092710 | ||
| 초록 | The activating leukocyte immunoglobulin-like receptors (LILRAs) play an important role in innate immunity. However, most of the LILRA members have not been characterized in avian species including chickens. The present study is the first attempt at cloning, structural analysis, and functional characterization of two LILRAs (LILRA2 and LILRA6) in chickens. Multiple sequence alignments and construction of a phylogenetic tree of chicken LILRA2 and LILRA6 with mammalian proteins revealed high conservation between chicken LILRA2 and LILRA6, and a close relationship between the chicken and mammalian proteins. The mRNA expression of LILRA2 and LILRA6 was high in chicken HD11 macrophages and the small intestine compared to that in several other tissues and cells tested. To examine the function of LILRA2 and LILRA6 in chicken immunity, LILRA2 and LILRA6 were transfected into HD11 cells. Our findings indicated that LILRA2 and LILRA6 are associated with the phosphorylation of Src kinases and SHP2 that play a regulatory role in immune functions. Moreover, LILRA6 associated with and activated MHC class I, β2-microglobulin, and induced the expression of transporters associated with antigen processing, but LILRA2 did not. Furthermore, both LILRA2 and LILRA6 activated JAK-STAT, NF-κB, PI3K/AKT, and ERK1/2 MAPK signaling pathways, and induced Th1-, Th2-, and Th17-type cytokines, and Toll-like receptors. Collectively, this study indicates that LILRA2 and LILRA6 are essential for macrophage-mediated immune responses, and they have the potential to complement the innate and adaptive immune system against pathogens. | ||
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