국가과학기술지식정보서비스

국가연구개발성과정보

성과
논문 (학술지)

Enhanced Osteogenesis of Dental Pulp Stem Cells In Vitro Induced by Chitosan-PEG-Incorporated Calcium Phosphate Cement

저자, 논문 구분, 저자, 학술지명, ISSN, SCI(SCIE포함) 구분, 학술지 출판 일자, 볼륨, 페이지, 학술지 임팩트 팩터, 학술대회명, 학술대회 개최국, 키워드 항목으로 구성된 논문 상세조회를 제공하고 데이터가 없는 항목에 대해서는 출력
등록번호 - SCI 구분?
 ※구분 : SCI(SCIE포함), 비SCI
SCI
저자명 (주·공동저자) Woong-Sup Lee; Jinsub Han; Jae Woon Lim; Seung Jeong; Myung Chul Lee; Woo-Young Yang; Hoon Seonwoo; B. Moon Kim; Yun-Hoon Choung; Kyoung-Je Jang; Jong Hoon Chung
논문구분 국외전문학술지 학술지명 Polymers
ISSN 2073-4360 학술지 출판일자 2021-07-09
학술지 볼륨번호 13(14) 논문페이지 2252 ~ 2267
학술지 임팩트팩터 4.329 기여율 0 %
초록
The use of bone graft materials is required for the treatment of bone defects damaged beyond the critical defect; therefore, injectable calcium phosphate cement (CPC) is actively used after surgery. The application of various polymers to improve injectability, mechanical strength, and biological function of injection-type CPC is encouraged. We previously developed a chitosan-PEG conjugate (CS/PEG) by a sulfur (VI) fluoride exchange reaction, and the resulting chitosan derivative showed high solubility at a neutral pH. We have demonstrated the CPC incorporated with a poly (ethylene glycol) (PEG)-grafted chitosan (CS/PEG) and developed CS/PEG CPC. The characterization of CS/PEG CPC was conducted using Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). The initial properties of CS/PEG CPCs, such as the pH, porosity, mechanical strength, zeta potential, and in vitro biocompatibility using the WST-1 assay, were also investigated. Moreover, osteocompatibility of CS/PEG CPCs was carried out via Alizarin Red S staining, immunocytochemistry, and Western blot analysis. CS/PEG CPC has enhanced mechanical strength compared to CPC, and the cohesion test also demonstrated in vivo stability. Furthermore, we determined whether CS/PEG CPC is a suitable candidate for promoting the osteogenic ability of Dental Pulp Stem Cells (DPSC). The elution of CS/PEG CPC entraps more calcium ion than CPC, as confirmed through the zeta potential test. Accordingly, the ion trapping effect of CS/PEG is considered to have played a role in promoting osteogenic differentiation of DPSCs. The results strongly suggested that CS/PEG could be used as suitable additives for improving osteogenic induction of bone substitute materials.
☞ 성과발생연도 2020년 이후 논문은 조사분석 미확정 정보이며, 조사분석 확정시 기여율 등 일부 정보가 변경될 수 있습니다.

※ 연구개발성과 등록 또는 활용에 대한 문의는 논문 연구개발성과 담당자를 통해 문의하시기 바랍니다.
    [문의] 한국과학기술정보연구원 Tel : 042)869-1894, E-mail : paper@kisti.re.kr
※ NTIS 관련 이용문의는 NTIS 콜센터(042-869-1115)로 문의하시기 바랍니다.
닫기버튼