논문 (학술지)
HMG-Like DSP1 Mediates Immune Responses of the Western Flower Thrips (Frankliniella occidentalis) Against Beauveria bassiana, a Fungal Pathogen
등록번호 | - | SCI 구분
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※구분 : SCI(SCIE포함), 비SCI |
SCI |
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저자명 (주·공동저자) | 샤비르 아흐메드; 최두열; 로이밀탄챈드라; 김용균 ※ 과제 참여정보와 일치하는 연구자 상세정보로 정확하지 않을 수 있습니다. 동일저자 논문보기 |
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논문구분 | 국외전문학술지 | 학술지명 | Frontiers in Immunology |
ISSN | 1664-3224 | 학술지 출판일자 | 2022-04-05 |
학술지 볼륨번호 | 13(0) | 논문페이지 | 1 ~ 17 |
학술지 임팩트팩터 | 7.561 | 기여율 | 100 % |
DOI | 10.3389/fimmu.2022.875239 | ||
초록 | The western flower thrips, Frankliniella occidentalis, is a polyphagous insect pest. It causes serious economic damage to crops directly by infesting host plants and indirectly by transmitting viral disease (1). Tomato spotted wilt virus (TSWV), a type species of Tospovirus and the only plantinfecting genus in the virus family of Bunyaviridae, can be effectively transmitted by F. occidentalis in a persistent-propagative fashion (2). However, it is difficult to control thrips with conventional synthetic insecticides due to their short life cycle (about 2 weeks), high fecundity, thigmotactic behavior, and insecticide resistance (3). Alternative control tactics have been introduced to effectively and nonchemically reduce populations of thrips (4, 5). Beauveria bassiana is an entomopathogenic fungus and an effective epizootic microorganism against F. occidentalis (6). It has been reported that B. bassiana application is effective in controlling F. occidentalis by reducing 70% of thrips’ population when its spore granules are applied to soil to infect pupae of thrips under greenhouse conditions (7). Furthermore, this fungal treatment can reduce the reproductive potential of thrips survived from exposure to a sublethal dose (8). On the other hand, the fungal pathogenicity is usually attenuated by the attack of various insect immune responses (9, 10). In thrips, immune responses are also likely to be effective in defending them against fungal infections (11). Insect immunity is innate and only programmed nonself molecular patterns such as eptidoglycans and b-1,3-glycan are induced upon bacterial and fungal infections, respectively (12). These nonself signals are recognized by pattern recognition receptors and then propagated by immune mediators to immune executive tissues such as hemocytes and fat body by exhibiting cellular and humoral immune responses (13). Cellular immune responses including phagocytosis, nodule formation, and encapsulation usually performed by hemocytes are acutely induced upon infections (14). Humoral immune responses then mop up the residual pathogens with toxic chemical reactions by producing various antimicrobial peptides (AMPs) or phenoloxidase to induce melanization (15). A recent discovery of damage-associated molecular pattern (DAMP) adds another type of nonself recognition to the insect immune system (16). Dorsal switch protein 1 (DSP1), an ortholog of vertebrate high mobility group box 1, is localized in the nucleus to modulate gene expression by regulating the binding of transcriptional factors to promoters (17). Upon immune challenge, it is released to plasma to act as a DAMP molecule and activate immune responses in coleopteran and lepidopteran insects (16, 18). From several RNA-seq analyses, a number of immuneassociated genes have been annotated in F. occidentalis (19). Indeed, TSWV can activate the immune system of F. occidentalis (20). The objective of this study was to determine the immune responses of F. occidentalis against B. bassiana infection. |
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