- 성과
- 논문 (학술지) AMPK-induced mitochondrial biogenesis decelerates retinal pigment epithelial cell degeneration under nutrient starvation
| 등록번호 | - |
SCI 구분
※구분 : SCI(SCIE포함), 비SCI
|
SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | -; | ||
| 논문구분 | 국외전문학술지 | 학술지명 | BMB Reports |
| ISSN | 1976-670X | 학술지 출판일자 | 2023-02-28 |
| 학술지 볼륨번호 | 55(0) | 논문페이지 | 1 ~ 000 |
| 학술지 임팩트팩터 | 5.041 | 기여율 | 100 % |
| DOI | https://doi.org/10.5483/BMBRep.2022.55.0.125 | ||
- 초록
- The implications of nutrient starvation due to aging on the degeneration of the retinal pigment epithelium (RPE) is yet to be fully explored. We examined the involvement of AMPK activation in mitochondrial homeostasis and its relationship with the maintenance of a healthy mitochondrial population and epithelial characteristics of RPE cells under nutrient starvation. Nutrient starvation induced mitochondrial senescence, which led to the accumulation of reactive oxygen species (ROS) in RPE cells. As nutrient starvation persisted, RPE cells underwent pathological epithelial-mesenchymal transition (EMT) via the upregulation of TWIST1, a transcription regulator which is activated by ROS-induced NF-κB signaling. Enhanced activation of AMPK with metformin decelerated mitochondrial senescence and EMT progression through mitochondrial biogenesis, primed by activation of PGC1-α. Thus, by facilitating mitochondrial biogenesis, AMPK protects RPE cells from the loss of epithelial integrity due to the accumulation of ROS in senescent mitochondria under nutrient starvation.
☞ 성과발생연도 2021년 이후 논문은 조사분석 미확정 정보이며, 조사분석 확정시 기여율 등 일부 정보가 변경될 수 있습니다.
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