- 성과
- 논문 (학술지) Mortality, growth, and egg production do not differ between non-transgenic and transgenic female chickens with ubiquitous expression of the 3D8 single chain variable fragment gene
| 등록번호 | - |
SCI 구분
※구분 : SCI(SCIE포함), 비SCI
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SCI |
|---|---|---|---|
| 저자명 (주·공동저자) | 양현 ; 김석호; 노진구; 박미령; 오건봉; 옥선아; 이민국; 이보람; 이승훈; 조용진; 정선근; 위하연; 변승준 ※ 과제 참여정보와 일치하는 연구자 상세정보로 정확하지 않을 수 있습니다. 동일저자 논문보기 |
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| 논문구분 | 국외전문학술지 | 학술지명 | POULTRY SCIENCE |
| ISSN | 1525-3171 | 학술지 출판일자 | 2023-08-31 |
| 학술지 볼륨번호 | 102(8) | 논문페이지 | 1 ~ 6 |
| 학술지 임팩트팩터 | 90.16393 | 기여율 | 100 % |
- 초록
- To date, many transgenic (TG) chicken lines have been developed, but few studies have performed a comparative analysis of their mortality, growth, and egg productivity. Previously, we reported the production of 3D8 scFv TG chickens showing antiviral activity. Here, we performed a biometric characterization of TG offspring female chickens. We selected 40 TG and 40 non-TG offspring female chicks among newly hatched chicks produced via artificial insemination of semen from heterotypic 3D8 scFv males into wild type female chickens. Serum was collected at 14 weeks of age, and serum concentrations of biochemical parameters, cytokines, and sex hormones were analyzed. Mortality and growth were monitored daily from 1 to 34 weeks, egg productivity was monitored daily from 20 to 34 weeks, and the weekly average values were used for analyses. Some serum parameters and cytokines were significantly different between non-TG and TG offspring female chickens. The levels of phosphorus (PHOS), total protein (TP), albumin (ALB), globulin (GLOB), and alanine aminotransferase (ALT) were significantly higher in non-TG chickens (p<0.05). The levels of alkaline phosphatase (ALP) and gamma-glutamyltransferase (GGT) were significantly higher in TG chickens (p<0.05). The levels of insulin growth factor-1 (IGF-1), interferon-gamma (INF-γ), interleukin-4 (IL-4), and IL-8 were significantly lower in TG chickens (p<0.05). Despite these differences, the mortality rates, body weight, egg production rates, and egg weight were not significantly different in the experimental groups of non-TG and TG offspring female chickens (p>0.05). In conclusion, ubiquitous expression of the 3D8 scFv gene in TG offspring female chickens does not affect some biometric characteristics, including mortality, growth, and egg productivity.
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