Gancaonin N from Glycyrrhiza uralensis Attenuates the Inflammatory Response by Downregulating the NF-κB/MAPK Pathway on an Acute Pneumonia In Vitro Model

출처 : Pharmaceutics
등록일 : 2021-07-06
조회 : 236

<div style="text-align: justify;" align="justify"><span style="font-family: 돋움, dotum; font-size: 11pt; color: rgb(58, 50, 195);"><span style="color: rgb(0, 0, 0); font-family: 돋움, dotum; font-size: 11pt;"></span></span><span style="color: rgb(34, 34, 34); font-family: 돋움, dotum; background-color: rgb(255, 255, 255); font-size: 11pt;">Acute pneumonia is an inflammatory disease caused by several pathogens, with symptoms such as fever and chest pain, to which children are particularly vulnerable. Gancaonin N is a prenylated isoflavone of&nbsp;</span><span class="html-italic" style="box-sizing: border-box; max-height: 1e+06px; font-style: italic; display: inline; color: rgb(34, 34, 34); font-family: 돋움, dotum; background-color: rgb(255, 255, 255); font-size: 11pt;">Glycyrrhiza uralensis</span><span style="color: rgb(34, 34, 34); font-family: 돋움, dotum; background-color: rgb(255, 255, 255); font-size: 11pt;">&nbsp;that has been used in the treatment of various diseases in oriental medicine. There are little data on the anti-inflammatory efficacy of Gancaonin N, and its effects and mechanisms on acute pneumonia are unknown. Therefore, this study was conducted as a preliminary analysis of the anti-inflammatory effect of Gancaonin N in lipopolysaccharide (LPS)-induced RAW264.7 cells, and to identify its preventive effect on the lung inflammatory response and the molecular mechanisms underlying it. In this study, Gancaonin N inhibited the production of NO and PGE2 in LPS-induced RAW264.7 cells and significantly reduced the expression of iNOS and COX-2 proteins at non-cytotoxic concentrations. In addition, in LPS-induced A549 cells, Gancaonin N significantly reduced the expression of COX-2 and pro-inflammatory cytokines, such as TNF-α, IL-1β, and IL-6. Moreover, Gancaonin N reduced MAPK signaling pathway phosphorylation and NF-κB nuclear translocation. Therefore, Gancaonin N relieved the inflammatory response by inactivating the MAPK and NF-κB signaling pathways; thus, it is a potential natural anti-inflammatory agent that can be used in the treatment of acute pneumonia.&nbsp;</span></div><div style="text-align: justify;" align="justify"><span style="color: rgb(34, 34, 34); font-family: 돋움, dotum; background-color: rgb(255, 255, 255); font-size: 11pt;"><br></span></div><div style="text-align: justify;" align="justify"><span style="background-color: rgb(255, 255, 255); font-size: 14.6667px;"><font color="#222222" face="돋움, dotum">👉[참고]<a href="http://news.kmib.co.kr/article/view.asp?arcid=0016073004&code=61121911&cp=kd" target="_blank">&nbsp;</a></font></span><font color="#222222" face="돋움, dotum"><span style="font-size: 14.6667px;"><a href="http://news.kmib.co.kr/article/view.asp?arcid=0016073004&code=61121911&cp=kd" target="_blank">역시 약방의 감초?…‘감초’에서 항염증 성분 찾아냈다</a>(국민일보, 2021.07.20)</span></font></div><div style="text-align: justify;" align="justify"><span style="font-family: 돋움, dotum; font-size: 11pt; color: rgb(58, 50, 195);"><span style="color: rgb(0, 0, 0);"><br></span></span></div><div style="text-align: justify;" align="justify"><span style="font-family: 돋움, dotum; font-size: 11pt; color: rgb(58, 50, 201);">※ 자세한 내용은 URL을 확인하시기 바랍니다.</span></div>

URL : https://www.mdpi.com/1999-4923/13/7/1028

태그 : #건강 #만성질환 #폐렴 #만성폐쇄성질환 #감초 #호흡기질병 #간카오닌N #항염증 #MAPK #한약재 #사회문제 #사회문제해결 #사회문제해결플랫폼