Probiotics-derived metabolite ameliorates skin allergy by promoting differentiation of FOXP3+ regulatory T cells

출처 : The Journal of Allergy and Clinical Immunology
등록일 : 2020-12-14
조회 : 157

<div style="text-align: justify; line-height: 1.8;" align="justify"><span style="font-size: 11pt;">Probiotics have shown their potent immunomodulatory effects and are considered a promising alternative for the prevention and treatment of inflammatory disorders. 1 However, lack of precise action mechanisms of probiotics restrained their application, especially for the treatment of non-gastrointestinal diseases such as skin allergies including atopic dermatitis and allergic contact dermatitis. 2 Previously, we have shown that the combination of rationally selected 5 probiotic bacteria strains (known as IRT5) has persuasive therapeutic effects on autoimmunity. 3 However, it is still unclear how oral supplementation of IRT5 modulates the immune system and eventually has therapeutic efficacy in skin allergies such as contact dermatitis and atopic dermatitis.</span></div><div style="text-align: justify; " align="justify"><br></div><div style="text-align: justify; line-height: 1.8;" align="justify"><span style="font-size: 11pt;">[참고] <a href="http://www.segye.com/newsView/20210124507651" target="_blank">세계일보, "아토피 등 피부 알레르기, 프로바이오틱스로 치료 길 열려”, (2021.01.24)</a></span></div><div><br></div>

URL : https://www.jacionline.org/article/S0091-6749(20)31727-9/fulltext

태그 : #건강 #만성질환 #아토피 #피부알레르기 #알러지 #프로바이오틱스 #IRT5 #락토바실러스 카제이 #락토바실러스 아시도필루스 #락토바실러스 루테리 #비피도박테리움비피 덤 #스트렙토코커스 서모필러스 #집진드기 #면역조절 T세포 #장내 미생물 #사회문제 #사회문제해결 #사회문제해결플랫폼